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What medications affect folate?

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    Posted: October 17 2010 at 4:47am
What medications affect folate?

Medications that can help deplete the body's supply of folate include: anticancer drugs like methotrexate; cholesterol-lowering drugs like cholestyramine; anti-inflammatory drugs like sulfasalazine; biguanide drugs like buformin, phenformin, or metformin used in the treatment of diabetes; birth control pills (oral contraceptives); potassium-sparing diuretics like triamterene; and antibiotics like trimethoprim or pyrimethamine. While the anti-convulsant drug phenytoin (sold under the brand name of Dilantin or Phenytek) remains somewhat controversial in terms of its impact on folate, several animal studies have shown a lowering of the liver's ability to make polyglutamyl forms of this vitamin following adminstration of phenytoin.

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