QuoteReplyTopic: What medications affect folate? Posted: October 17 2010 at 4:47am
What medications affect folate?
Medications that can help deplete the body's supply of folate include:
anticancer drugs like methotrexate; cholesterol-lowering drugs like
cholestyramine; anti-inflammatory drugs like sulfasalazine; biguanide
drugs like buformin, phenformin, or metformin used in the treatment of
diabetes; birth control pills (oral contraceptives); potassium-sparing
diuretics like triamterene; and antibiotics like trimethoprim or
pyrimethamine. While the anti-convulsant drug phenytoin (sold under the
brand name of Dilantin or Phenytek) remains somewhat controversial in
terms of its impact on folate, several animal studies have shown a
lowering of the liver's ability to make polyglutamyl forms of this
vitamin following adminstration of phenytoin.
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